Journal Article

FZJ-2012-00877

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Reelin Together with ApoER2 Regulates Interneuron Migration in the Olfactory Bulb

Hellwig, S. ; Hack, I.FZJ* ; Zucker, B. ; Brunne, B. ; Junghans, D.

2012
PLoS Lawrence, Kan.

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Please use a persistent id in citations: http://hdl.handle.net/2128/4888  doi:10.1371/journal.pone.0050646

Abstract: One pathway regulating the migration of neurons during development of the mammalian cortex involves the extracellular matrix protein Reelin. Reelin and components of its signaling cascade, the lipoprotein receptors ApoER2 and Vldlr and the intracellular adapter protein Dab1 are pivotal for a correct layer formation during corticogenesis. The olfactory bulb (OB) as a phylogenetically old cortical region is known to be a prominent site of Reelin expression. Although some aspects of Reelin function in the OB have been described, the influence of Reelin on OB layer formation has so far been poorly analyzed. Here we studied animals deficient for either Reelin, Vldlr, ApoER2 or Dab1 as well as double-null mutants. We performed organotypic migration assays, immunohistochemical marker analysis and BrdU incorporation studies to elucidate roles for the different components of the Reelin signaling cascade in OB neuroblast migration and layer formation. We identified ApoER2 as being the main receptor responsible for Reelin mediated detachment of neuroblasts and correct migration of early generated interneurons within the OB, a prerequisite for correct OB lamination

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Contributing Institute(s):

1. Molekulare Organisation des Gehirns (INM-2)

Research Program(s):

1. 331 - Signalling Pathways and Mechanisms in the Nervous System (POF2-331) (POF2-331)
2. 89571 - Connectivity and Activity (POF2-89571) (POF2-89571)

Appears in the scientific report 2012

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Database coverage:
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