Selective drug trace detection with low-field NMR

Glöggler, S.; Mueller, R.; Emondts, M.; Appelt, S.; Blümich, B.; Colell, J.

doi:10.1039/c0an01048k

Journal Article

PreJuSER-18246

Selective drug trace detection with low-field NMR

Glöggler, S. ; Emondts, M.FZJ* ; Colell, J.FZJ* ; Mueller, R.FZJ* ; Blümich, B. ; Appelt, S.FZJ*

2011
Soc. Cambridge

The analyst 136, 1566 - 1568 (2011) [10.1039/c0an01048k]

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Please use a persistent id in citations: http://hdl.handle.net/2128/7362 doi:10.1039/c0an01048k

Abstract: Advances with para-hydrogen induced polarization open up new fields of applications for portable low-field NMR. Here we report the possibility of tracing drugs down to the micromolar regime. We could selectively polarize nicotine quantities similar to those found in one cigarette. Also less than 1 mg of harmine, a drug used for treatment of Parkinson's disease, and morphine extracted from an opium solution were detectable after polarization with para-hydrogen in single-scan (1)H-experiments. Moreover, we demonstrate the possibility to selectively enhance and detect the (1)H-signal of drug molecules with PHIP in proton rich standard solutions that would otherwise mask the (1)H NMR signal of the drug.

Keyword(s): Drug Residues: analysis (MeSH) ; Harmine: analysis (MeSH) ; Hydrogen: chemistry (MeSH) ; Magnetic Resonance Spectroscopy: methods (MeSH) ; Morphine: analysis (MeSH) ; Nicotine: analysis (MeSH) ; Opium: chemistry (MeSH) ; Tobacco: chemistry (MeSH) ; Hydrogen ; Harmine ; Nicotine ; Morphine ; Opium ; J