Plant metal chaperones: a novel perspective in dementia therapy

Kastenholz, B.; Nagel, K. A.; Garfin, D.E.; Horst, J.

doi:10.1080/13506120902879392

Journal Article

PreJuSER-3433

Plant metal chaperones: a novel perspective in dementia therapy

Kastenholz, B.FZJ* ; Garfin, D. E. ; Horst, J. ; Nagel, K. A.FZJ*

2009
Informa Healthcare London [u.a.]

Amyloid 16, 81 - 83 (2009) [10.1080/13506120902879392]

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Please use a persistent id in citations: doi:10.1080/13506120902879392

Abstract: Dys-homeostasis of copper metabolism and oxidative stress are major hallmarks in the brains of Alzheimer patients. Therefore, metal bioavailability and mechanisms of copper ion homeostasis throughout the body are crucial and potential targets for therapeutic agents. Many of the medications used or suggested, respectively, at present time, may either be toxic, reveal a lack of specificity or have unknown mechanisms of action in vivo. Metal chaperones from medicinal plants are proposed as medications that are relatively free from these disadvantages. Furthermore, these agents are a promising class of molecules for studies aimed at developing innovative and etiological treatments for protein-misfolding diseases, especially Alzheimer's disease.

Keyword(s): Copper: chemistry (MeSH) ; Copper: metabolism (MeSH) ; Dementia: drug therapy (MeSH) ; Homeostasis (MeSH) ; Humans (MeSH) ; Molecular Chaperones: chemistry (MeSH) ; Molecular Chaperones: therapeutic use (MeSH) ; Oxidative Stress (MeSH) ; Plants: chemistry (MeSH) ; Molecular Chaperones ; Copper ; J ; Metal chaperones (auto) ; Alzheimer's disease (auto) ; biochemical impact (auto) ; SOD-1 (auto) ; CCS (auto) ; A beta (auto)