Journal Article

FZJ-2017-03092

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512

Palermo, G. ; Minniti, E. ; Greco, M. L. ; Riccardi, L. ; Simoni, E. ; Convertino, M. ; Marchetti, C. ; Rosini, M. ; Sissi, C. ; Minarini, A. ; De Vivo, M. (Corresponding author)FZJ*

2015
Soc. Cambridge

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Please use a persistent id in citations: http://hdl.handle.net/2128/14219  doi:10.1039/C5CC05065K

Abstract: Combined computational–experimental analyses explain and quantify the spermine-vectorized F14512's boosted potency as a topoII poison. We found that an optimized polyamine moiety boosts drug binding to the topoII/DNA cleavage complex, rather than to the DNA alone. These results provide new structural bases and key reference data for designing new human topoII poisons.

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Contributing Institute(s):

1. Computational Biomedicine (IAS-5)
2. Computational Biomedicine (INM-9)

Research Program(s):

1. 899 - ohne Topic (POF3-899) (POF3-899)

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Database coverage:
; ; ; Allianz-Lizenz / DFG ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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