Journal Article

FZJ-2017-03465

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Does metabolite channeling accelerate enzyme-catalyzed cascade reactions?

Poshyvailo, L.FZJ* ; von Lieres, E.FZJ* ; Kondrat, S. (Corresponding author)FZJ*

2017
PLoS Lawrence, Kan.

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Please use a persistent id in citations: http://hdl.handle.net/2128/14357  doi:10.1371/journal.pone.0172673

Abstract: Metabolite or substrate channeling is a direct transfer of metabolites from one enzyme to the next enzyme in a cascade. Among many potential advantages of substrate channeling, acceleration of the total reaction rate is considered as one of the most important and self-evident. However, using a simple model, supported by stochastic simulations, we show that it is not always the case; particularly at long times (i.e. in steady state) and high substrate concentrations, a channeled reaction cannot be faster, and can even be slower, than the original non-channeled cascade reaction. In addition we show that increasing the degree of channeling may lead to an increase of the metabolite pool size. We substantiate that the main advantage of channeling likely lies in protecting metabolites from degradation or competing side reactions.

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Contributing Institute(s):

1. Stratosphäre (IEK-7)
2. Biotechnologie (IBG-1)

Research Program(s):

1. 583 - Innovative Synergisms (POF3-583) (POF3-583)
2. HITEC - Helmholtz Interdisciplinary Doctoral Training in Energy and Climate Research (HITEC) (HITEC-20170406) (HITEC-20170406)

Appears in the scientific report 2017

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