Journal Article

FZJ-2017-06411

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Printed microfluidic filter for heparinized blood

Bilatto, S. E. R. ; Adly, N.FZJ* ; Correa, D. S. ; Wolfrum, B.FZJ* ; Offenhäusser, A.FZJ* ; Yakushenko, A. (Corresponding author)FZJ*

2017
AIP Melville, NY

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Please use a persistent id in citations: http://hdl.handle.net/2128/18157  doi:10.1063/1.4982963

Abstract: A simple lab-on-a-chip method for blood plasma separation was developed by combining stereolithographic 3D printing with inkjet printing, creating a completely sealed microfluidic device. In some approaches, one dilutes the blood sample before separation, reducing the concentration of a target analyte and increasing a contamination risk. In this work, a single drop (8 μl) of heparinized whole blood could be efficiently filtered using a capillary effect without any external driving forces and without dilution. The blood storage in heparin tubes during 24 h at 4 °C initiated the formation of small crystals that formed auto-filtration structures in the sample upon entering the 3D-printed device, with pores smaller than the red blood cells, separating plasma from the cellular content. The total filtration process took less than 10 s. The presented printed plasma filtration microfluidics fabricated with a rapid prototyping approach is a miniaturized, fast and easy-to-operate device that can be integrated into healthcare/portable systems for point-of-care diagnostics.

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Contributing Institute(s):

1. Bioelektronik (ICS-8)

Research Program(s):

1. 523 - Controlling Configuration-Based Phenomena (POF3-523) (POF3-523)

Appears in the scientific report 2017

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Database coverage:
; ; BIOSIS Previews ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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