Journal Article

FZJ-2019-05345

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier

Schell, C. ; Sabass, B.FZJ* ; Helmstaedter, M. ; Geist, F. ; Abed, A. ; Yasuda-Yamahara, M. ; Sigle, A. ; Maier, J. I. ; Grahammer, F. ; Siegerist, F. ; Artelt, N. ; Endlich, N. ; Kerjaschki, D. ; Arnold, H.-H. ; Dengjel, J. ; Rogg, M. ; Huber, T. B. (Corresponding author)

2018
Elsevier New York, NY

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Please use a persistent id in citations: http://hdl.handle.net/2128/23219  doi:10.1016/j.devcel.2018.11.011

Abstract: Podocytes, highly specialized epithelial cells, build the outer part of the kidney filtration barrier and withstand high mechanical forces through a complex network of cellular protrusions. Here, we show that Arp2/3-dependent actin polymerization controls actomyosin contractility and focal adhesion maturation of podocyte protrusions and thereby regulates formation, maintenance, and capacity to adapt to mechanical requirements of the filtration barrier. We find that N-WASP-Arp2/3 define the development of complex arborized podocyte protrusions in vitro and in vivo. Loss of dendritic actin networks results in a pronounced activation of the actomyosin cytoskeleton and the generation of over-maturated but less efficient adhesion, leading to detachment of podocytes. Our data provide a model to explain podocyte protrusion morphology and their mechanical stability based on a tripartite relationship between actin polymerization, contractility, and adhesion.

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Contributing Institute(s):

1. Theorie der Weichen Materie und Biophysik (ICS-2)

Research Program(s):

1. 553 - Physical Basis of Diseases (POF3-553) (POF3-553)

Appears in the scientific report 2019

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Database coverage:
; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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