Journal Article

FZJ-2020-02891

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Preparation of labeled aromatic amino acids via late-stage 18 F-fluorination of chiral nickel and copper complexes

Craig, A. ; Kolks, N.FZJ* ; Urusova, E.FZJ* ; Zischler, J. ; Brugger, M.FZJ* ; Endepols, H.FZJ* ; Neumaier, B. (Corresponding author)FZJ* ; Zlatopolskiy, B. D.

2020
Soc. Cambridge

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Please use a persistent id in citations: http://hdl.handle.net/2128/25630  doi:10.1039/D0CC02223C

Abstract: A general protocol for the preparation of 18F-labeled AAAs and α-methyl-AAAs applying alcohol-enhanced Cu-mediated radiofluorination of Bpin-substituted chiral complexes using Ni/Cu-BPX templates as double protecting groups is reported. The chiral auxiliaries are easily accessible from commercially available starting materials in a few synthetic steps. The versatility of the method was demonstrated by the high-yielding preparation of a series of [18F]F-AAAs and the successful implementation of the protocol into automated radiosynthesis modules.

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Contributing Institute(s):

1. Nuklearchemie (INM-5)

Research Program(s):

1. 573 - Neuroimaging (POF3-573) (POF3-573)

Appears in the scientific report 2020

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Database coverage:
; ; Allianz-Lizenz / DFG ; Chemical Reactions ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; Index Chemicus ; JCR ; NCBI Molecular Biology Database ; National-Konsortium ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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