Journal Article

FZJ-2020-04015

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Anatomy of nerve fiber bundles at micrometer-resolution in the vervet monkey visual system

Takemura, H. (Corresponding author) ; Palomero-Gallagher, N. (Corresponding author)FZJ* ; Axer, M.FZJ* ; Grässel, D.FZJ* ; Jorgensen, M. J. ; Woods, R. ; Zilles, K.FZJ*

2020
eLife Sciences Publications Cambridge

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Please use a persistent id in citations: http://hdl.handle.net/2128/25897  doi:10.7554/eLife.55444

Abstract: Although the primate visual system has been extensively studied, detailed spatial organization of white matter fiber tracts carrying visual information between areas has not been fully established. This is mainly due to the large gap between tracer studies and diffusion-weighted MRI studies, which focus on specific axonal connections and macroscale organization of fiber tracts, respectively. Here we used 3D polarization light imaging (3D-PLI), which enables direct visualization of fiber tracts at micrometer resolution, to identify and visualize fiber tracts of the visual system, such as stratum sagittale, inferior longitudinal fascicle, vertical occipital fascicle, tapetum and dorsal occipital bundle in vervet monkey brains. Moreover, 3D-PLI data provide detailed information on cortical projections of these tracts, distinction between neighboring tracts, and novel short-range pathways. This work provides essential information for interpretation of functional and diffusion-weighted MRI data, as well as revision of wiring diagrams based upon observations in the vervet visual system.

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)
2. JARA - HPC (JARA-HPC)

Research Program(s):

1. 571 - Connectivity and Activity (POF3-571) (POF3-571)
2. HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907) (785907)
3. HBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539) (945539)
4. 3D Reconstruction of Nerve Fibers in the Human, the Monkey, the Rodent, and the Pigeon Brain (jinm11_20191101) (jinm11_20191101)

Appears in the scientific report 2020

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