Journal Article

FZJ-2020-04607

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Convergence of cortical types and functional motifs in the human mesiotemporal lobe

Paquola, C. (Corresponding author) ; Benkarim, O. ; DeKraker, J. ; Larivière, S. ; Frässle, S. ; Royer, J. ; Tavakol, S. ; Valk, S.FZJ* ; Bernasconi, A. ; Bernasconi, N. ; Khan, A. ; Evans, A. C. ; Razi, A. ; Smallwood, J. ; Bernhardt, B. C.

2020
eLife Sciences Publications Cambridge

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Please use a persistent id in citations: http://hdl.handle.net/2128/26237  doi:10.7554/eLife.60673

Abstract: The mesiotemporal lobe (MTL) is implicated in many cognitive processes, is compromised in numerous brain disorders, and exhibits a gradual cytoarchitectural transition from six-layered parahippocampal isocortex to three-layered hippocampal allocortex. Leveraging an ultra-high-resolution histological reconstruction of a human brain, our study showed that the dominant axis of MTL cytoarchitectural differentiation follows the iso-to-allocortical transition and depth-specific variations in neuronal density. Projecting the histology-derived MTL model to in-vivo functional MRI, we furthermore determined how its cytoarchitecture underpins its intrinsic effective connectivity and association to large-scale networks. Here, the cytoarchitectural gradient was found to underpin intrinsic effective connectivity of the MTL, but patterns differed along the anterior-posterior axis. Moreover, while the iso-to-allocortical gradient parametrically represented the multiple-demand relative to task-negative networks, anterior-posterior gradients represented transmodal versus unimodal networks. Our findings establish that the combination of micro- and macrostructural features allow the MTL to represent dominant motifs of whole-brain functional organisation.

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Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 572 - (Dys-)function and Plasticity (POF3-572) (POF3-572)

Appears in the scientific report 2020

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