Journal Article

FZJ-2021-01208

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Genetic and molecular characterization of multicomponent resistance of Pseudomonas against allicin

Borlinghaus, J. (Corresponding author) ; Bolger, A. ; Schier, C. ; Vogel, A. ; Usadel, B.FZJ* ; Gruhlke, M. C. ; Slusarenko, A. J.

2020
EMBO Press Heidelberg

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Please use a persistent id in citations: http://hdl.handle.net/2128/27272  doi:10.26508/lsa.202000670

Abstract: The common foodstuff garlic produces the potent antibiotic defense substance allicin after tissue damage. Allicin is a redox toxin that oxidizes glutathione and cellular proteins and makes garlic a highly hostile environment for non-adapted microbes. Genomic clones from a highly allicin-resistant Pseudomonas fluorescens (PfAR-1), which was isolated from garlic, conferred allicin resistance to Pseudomonas syringae and even to Escherichia coli. Resistance-conferring genes had redox-related functions and were on core fragments from three similar genomic islands identified by sequencing and in silico analysis. Transposon mutagenesis and overexpression analyses revealed the contribution of individual candidate genes to allicin resistance. Taken together, our data define a multicomponent resistance mechanism against allicin in PfAR-1, achieved through horizontal gene transfer.

Note: Rheinisch-Westfälische Technische Hochschule Aachen UniversityBundesministerium für Bildung und Forschung (BMBF) grant 031A536.

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Contributing Institute(s):

1. Bioinformatik (IBG-4)

Research Program(s):

1. 899 - ohne Topic (POF3-899) (POF3-899)

Appears in the scientific report 2021

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