Journal Article

FZJ-2021-02024

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Distribution of the noradrenaline innervation and adrenoceptors in the macaque monkey thalamus

Pérez-Santos, I. ; Palomero-Gallagher, N. (Corresponding author)FZJ* ; Zilles, K.FZJ* ; Cavada, C. (Corresponding author)

2021
Oxford Univ. Press Oxford

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Please use a persistent id in citations: http://hdl.handle.net/2128/28416  doi:10.1093/cercor/bhab073

Abstract: Noradrenaline (NA) in the thalamus has important roles in physiological, pharmacological, and pathological neuromodulation. In this work, a complete characterization of NA axons and Alpha adrenoceptors distributions is provided.NA axons, revealed by immunohistochemistry against the synthesizing enzyme and the NA transporter, are present in all thalamic nuclei. The most densely innervated ones are the midline nuclei, intralaminar nuclei (paracentral and parafascicular), and the medial sector of the mediodorsal nucleus (MDm). The ventral motor nuclei and most somatosensory relay nuclei receive a moderate NA innervation. The pulvinar complex receives a heterogeneous innervation. The lateral geniculate nucleus (GL) has the lowest NA innervation.Alpha adrenoceptors were analyzed by in vitro quantitative autoradiography. Alpha-1 receptor densities are higher than Alpha-2 densities. Overall, axonal densities and Alpha adrenoceptor densities coincide; although some mismatches were identified. The nuclei with the highest Alpha-1 values are MDm, the parvocellular part of the ventral posterior medial nucleus, medial pulvinar, and midline nuclei. The nucleus with the lowest Alpha-1 receptor density is GL. Alpha-2 receptor densities are highest in the lateral dorsal, centromedian, medial and inferior pulvinar, and midline nuclei.These results suggest a role for NA in modulating thalamic involvement in consciousness, limbic, cognitive, and executive functions.

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)

Research Program(s):

1. 525 - Decoding Brain Organization and Dysfunction (POF4-525) (POF4-525)
2. HBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539) (945539)
3. HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907) (785907)
4. 3D-MMA - 3D-MMA-Gradienten der Verteilung multipler Transmitterrezeptoren in der Hirnrinde als Grundlage verteilter kognitiver, sensorischer und motorischer Funktionen (BMBF-01GQ1902) (BMBF-01GQ1902)

Appears in the scientific report 2021

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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