Gast ::
| Hauptseite > Publikationsdatenbank > Maintaining proteostasis under mechanical stress |
| Hauptseite > Publikationsdatenbank > Maintaining proteostasis under mechanical stress |
| Journal Article | FZJ-2021-03072 |
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
2021
Wiley
Hoboken, NJ [u.a.]
This record in other databases: 
Please use a persistent id in citations: http://hdl.handle.net/2128/28422 doi:10.15252/embr.202152507
Abstract: Cell survival, tissue integrity and organismal health depend on the ability to maintain functional protein networks even under conditions that threaten protein integrity. Protection against such stress conditions involves the adaptation of folding and degradation machineries, which help to preserve the protein network by facilitating the refolding or disposal of damaged proteins. In multicellular organisms, cells are permanently exposed to stress resulting from mechanical forces. Yet, for long time mechanical stress was not recognized as a primary stressor that perturbs protein structure and threatens proteome integrity. The identification and characterization of protein folding and degradation systems, which handle force-unfolded proteins, marks a turning point in this regard. It has become apparent that mechanical stress protection operates during cell differentiation, adhesion and migration and is essential for maintaining tissues such as skeletal muscle, heart and kidney as well as the immune system. Here, we provide an overview of recent advances in our understanding of mechanical stress protection.
; 
; 
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF >= 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection
|
The record appears in these collections: |
PDF
Fulltext by OpenAccess repository