Journal Article

FZJ-2022-01095

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png mGluR 5 and GABA A receptor‐specific parametric PET atlas construction— PET / MR data processing pipeline, validation, and application

Kaulen, N.FZJ* ; Rajkumar, R.FZJ* ; Régio Brambilla, C.FZJ* ; Mauler, J.FZJ* ; Ramkiran, S.FZJ* ; Orth, L. ; Sbaihat, H.FZJ* ; Lang, M.FZJ* ; Wyss, C. ; Rota Kops, E.FZJ* ; Scheins, J.FZJ* ; Neumaier, B.FZJ* ; Ermert, J.FZJ* ; Herzog, H.FZJ* ; Langen, K.-J.FZJ* ; Lerche, C.FZJ* ; Shah, N. J.FZJ* ; Veselinović, T.RWTH* ; Neuner, I. (Corresponding author)FZJ*

2022
Wiley-Liss New York, NY

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Please use a persistent id in citations: http://hdl.handle.net/2128/31060  doi:10.1002/hbm.25778

Abstract: The glutamate and γ-aminobutyric acid neuroreceptor subtypes mGluR5 and GABAA are hypothesized to be involved in the development of a variety of psychiatric diseases. However, detailed information relating to their in vivo distribution is generally unavailable. Maps of such distributions could potentially aid clinical studies by providing a reference for the normal distribution of neuroreceptors and may also be useful as covariates in advanced functional magnetic resonance imaging (MR) studies. In this study, we propose a comprehensive processing pipeline for the construction of standard space, in vivo distributions of non-displaceable binding potential (BPND), and total distribution volume (VT) based on simultaneously acquired bolus-infusion positron emission tomography (PET) and MR data. The pipeline was applied to [11C]ABP688-PET/MR (13 healthy male non-smokers, 26.6 ± 7.0 years) and [11C]Flumazenil-PET/MR (10 healthy males, 25.8 ± 3.0 years) data. Activity concentration templates, as well as VT and BPND atlases of mGluR5 and GABAA, were generated from these data. The maps were validated by assessing the percent error δ from warped space to native space in a selection of brain regions. We verified that the average δABP = 3.0 ± 1.0% and δFMZ = 3.8 ± 1.4% were lower than the expected variabilities σ of the tracers (σABP = 4.0%–16.0%, σFMZ = 3.9%–9.5%). An evaluation of PET-to-PET registrations based on the new maps showed higher registration accuracy compared to registrations based on the commonly used [15O]H2O-template distributed with SPM12. Thus, we conclude that the resulting maps can be used for further research and the proposed pipeline is a viable tool for the construction of standardized PET data distributions.

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Contributing Institute(s):

1. Jara-Institut Quantum Information (INM-11)
2. Physik der Medizinischen Bildgebung (INM-4)
3. Jülich-Aachen Research Alliance - Translational Brain Medicine (JARA-BRAIN)
4. Nuklearchemie (INM-5)

Research Program(s):

1. 5253 - Neuroimaging (POF4-525) (POF4-525)

Appears in the scientific report 2022

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