Journal Article

FZJ-2022-03038

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Neural mechanisms underlying Social Recognition and Theory of Mind in Adolescent Patients with Bulimia Nervosa and Transdiagnostic Comparison with Anorexia Nervosa

Ruan, V. A. (Corresponding author)RWTH* ; Hartz, A. ; Hueck, M. ; Dahmen, B. ; von Polier, G.FZJ* ; Herpertz-Dahlmann, B. ; Konrad, K.FZJ* ; Schulte-Rüther, M.FZJ* ; Seitz, J.

2022
Wiley Chichester

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Please use a persistent id in citations: http://hdl.handle.net/2128/31689  doi:10.1002/erv.2911

Abstract: IntroductionTheory of mind (ToM) is important for social interactions and typical development and has been found to be impaired in patients with anorexia nervosa (AN) and bulimia nervosa (BN). Hypoactivation in frontotemporal brain regions seems to be the underlying neural mechanism in AN while whole-brain analyses in BN are lacking.MethodsWe used the well-validated social recognition task fMRI paradigm to assess ToM in a total of 72 female adolescents (16 BN, 18 AN and 38 matched healthy controls [HC]).ResultsCompared to HCBN, patients with BN showed hyperactivity during ToM-activity in the right frontal pole, middle temporal gyrus and left temporal pole and differed fundamentally from hypoactivation in these regions observed in patients with AN before and after short-term weight rehabilitation. Interaction and overlap analyses confirmed that similar regions were affected in opposite directions in both diseases. Hyperactivations in BN in the right middle temporal gyrus and right frontal pole were associated with clinical BN-severity markers binging and purging frequency.DiscussionThe hyperactivation in BN suggest different underlying neural mechanisms for ToM compared to AN. Hyperactivity might correspond to a different but also ineffective cognitive style in patients with BN when approaching social interactions. These important transdiagnostic differences are relevant for future brain-targeted therapeutic approaches.

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Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 5252 - Brain Dysfunction and Plasticity (POF4-525) (POF4-525)

Appears in the scientific report 2022

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Database coverage:
; ; ; Current Contents - Social and Behavioral Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; SCOPUS ; Social Sciences Citation Index ; Thomson Reuters Master Journal List

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