Journal Article

FZJ-2022-03278

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Clinical and imaging evidence of brain-first and body-first Parkinson's disease

Horsager, J. (Corresponding author) ; Knudsen, K. ; Sommerauer, M.FZJ*

2022
Academic Press Orlando, Fla.

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Please use a persistent id in citations: http://hdl.handle.net/2128/31815  doi:10.1016/j.nbd.2022.105626

Abstract: Braak's hypothesis has been extremely influential over the last two decades. However, neuropathological and clinical evidence suggest that the model does not conform to all patients with Parkinson's disease (PD). To resolve this controversy, a new model was recently proposed; in brain-first PD, the initial α-synuclein pathology arise inside the central nervous system, likely rostral to the substantia nigra pars compacta, and spread via interconnected structures – eventually affecting the autonomic nervous system; in body-first PD, the initial pathological α-synuclein originates in the enteric nervous system with subsequent caudo-rostral propagation to the autonomic and central nervous system.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 5252 - Brain Dysfunction and Plasticity (POF4-525) (POF4-525)

Appears in the scientific report 2022

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Database coverage:
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