Journal Article

FZJ-2022-04082

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Resting state EEG power spectrum and functional connectivity in autism: a cross-sectional analysis

Garcés, P. (Corresponding author) ; Baumeister, S. ; Mason, L. ; Chatham, C. H. ; Holiga, S. ; Dukart, J.FZJ* ; Jones, E. J. H. ; Banaschewski, T. ; Baron-Cohen, S. ; Bölte, S. ; Buitelaar, J. K. ; Durston, S. ; Oranje, B. ; Persico, A. M. ; Beckmann, C. F. ; Bougeron, T. ; Dell’Acqua, F. ; Ecker, C. ; Moessnang, C. ; Charman, T. ; Tillmann, J. ; Murphy, D. G. M. ; Johnson, M. ; Loth, E. ; Brandeis, D. ; Hipp, J. F. ; Ahmad, J. ; Ambrosino, S. ; Auyeung, B. ; Banaschewski, T. ; Baron-Cohen, S. ; Baumeister, S. ; Beckmann, C. F. ; Bölte, S. ; Bourgeron, T. ; Bours, C. ; Brammer, M. ; Brandeis, D. ; Brogna, C. ; de Bruijn, Y. ; Buitelaar, J. K. ; Chakrabarti, B. ; Charman, T. ; Cornelissen, I. ; Crawley, D. ; Dell’Acqua, F. ; Dumas, G. ; Durston, S. ; Ecker, C. ; Faulkner, J. ; Frouin, V. ; Garcés, P. ; Goyard, D. ; Ham, L. ; Hayward, H. ; Hipp, J. ; Holt, R. ; Johnson, M. H. ; Jones, E. J. H. ; Kundu, P. ; Lai, M.-C. ; ardhuy, X. L. D. ; Lombardo, M. V. ; Loth, E. ; Lythgoe, D. J. ; Mandl, R. ; Marquand, A. ; Mason, L. ; Mennes, M. ; Meyer-Lindenberg, A. ; Moessnang, C. ; Mueller, N. ; Murphy, D. G. M. ; Oakley, B. ; O’Dwyer, L. ; Oldehinkel, M. ; Oranje, B. ; Pandina, G. ; Persico, A. M. ; Ruggeri, B. ; Ruigrok, A. ; Sabet, J. ; Sacco, R. ; Cáceres, A. S. J. ; Simonoff, E. ; Spooren, W. ; Tillmann, J. ; Toro, R. ; Tost, H. ; Waldman, J. ; Williams, S. C. R. ; Wooldridge, C. ; Zwiers, M. P.

2022
BioMed Central London

This record in other databases:      

Please use a persistent id in citations: http://hdl.handle.net/2128/32326  doi:10.1186/s13229-022-00500-x

Abstract: BackgroundUnderstanding the development of the neuronal circuitry underlying autism spectrum disorder (ASD) is critical to shed light into its etiology and for the development of treatment options. Resting state EEG provides a window into spontaneous local and long-range neuronal synchronization and has been investigated in many ASD studies, but results are inconsistent. Unbiased investigation in large and comprehensive samples focusing on replicability is needed.MethodsWe quantified resting state EEG alpha peak metrics, power spectrum (PS, 2–32 Hz) and functional connectivity (FC) in 411 children, adolescents and adults (n = 212 ASD, n = 199 neurotypicals [NT], all with IQ > 75). We performed analyses in source-space using individual head models derived from the participants’ MRIs. We tested for differences in mean and variance between the ASD and NT groups for both PS and FC using linear mixed effects models accounting for age, sex, IQ and site effects. Then, we used machine learning to assess whether a multivariate combination of EEG features could better separate ASD and NT participants. All analyses were embedded within a train-validation approach (70%–30% split).ResultsIn the training dataset, we found an interaction between age and group for the reactivity to eye opening (p = .042 uncorrected), and a significant but weak multivariate ASD vs. NT classification performance for PS and FC (sensitivity 0.52–0.62, specificity 0.59–0.73). None of these findings replicated significantly in the validation dataset, although the effect size in the validation dataset overlapped with the prediction interval from the training dataset.LimitationsThe statistical power to detect weak effects—of the magnitude of those found in the training dataset—in the validation dataset is small, and we cannot fully conclude on the reproducibility of the training dataset’s effects.ConclusionsThis suggests that PS and FC values in ASD and NT have a strong overlap, and that differences between both groups (in both mean and variance) have, at best, a small effect size. Larger studies would be needed to investigate and replicate such potential effects.

---

Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)

Appears in the scientific report 2022

---

Database coverage:
; ; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---