Talk (non-conference) (Outreach)

FZJ-2022-06000

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Detection of spatio-temporal spike patterns and multiple overlapping cell assemblies during motor behavior

Stella, A. (Corresponding author)FZJ* ; Grün, S.FZJ*

2022

Abstract: The cell assembly hypothesis postulates that information processing in the brain entails therepetitive co-activation of groups of neurons [1]. The activation of such assemblies wouldlead to spatio-temporal spike patterns (STPs) at the resolution of a few milliseconds. In orderto test the cell assembly hypothesis, we searched for significant STPs in parallel spike trains,and developed the SPADE method [2,3]. Using SPADE, we analyzed experimental data fromthe motor cortex (M1/PMd) of macaque monkeys (Macaca mulatta) performing areach-to-grasp task [4] and found an abundance of STPs. Quantitative analysis showed thatSTPs are functionally related to behavior, which suggests the presence of assembliesactivated during the task.References:[1] Hebb, D. O. (1949). John Wiley & Sons[2] Stella et al. (2019). Biosystems, 185, 104022. [doi: 10.1016/j.biosystems.2019.104022][3] Stella et al. (2022). eNeuro [doi: 10.1523/ENEURO.0505-21.2022][4] Brochier et al. (2018). Scientific data 5.1: 1-23. [doi: 10.12751/g-node.f83565]

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Contributing Institute(s):

1. Computational and Systems Neuroscience (INM-6)
2. Theoretical Neuroscience (IAS-6)
3. Jara-Institut Brain structure-function relationships (INM-10)

Research Program(s):

1. 5231 - Neuroscientific Foundations (POF4-523) (POF4-523)
2. HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907) (785907)
3. HBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539) (945539)
4. GRK 2416 - GRK 2416: MultiSenses-MultiScales: Neue Ansätze zur Aufklärung neuronaler multisensorischer Integration (368482240) (368482240)
5. HAF - Helmholtz Analytics Framework (ZT-I-0003) (ZT-I-0003)

Appears in the scientific report 2022

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