Contribution to a book

FZJ-2024-00599

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Fluoride Transport and Inhibition Across CLC Transporters

Fahlke, C. (Editor)FZJ* ; Asgharpour, S. ; Chi, L. A. ; Spehr, M.RWTH* ; Carloni, P. (Corresponding author)FZJ* ; Alfonso-Prieto, M. (Corresponding author)FZJ*

2024
Springer International Publishing Cham
ISBN: 978-3-031-51346-6, 978-3-031-51346-6 (electronic)

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Please use a persistent id in citations: doi:10.1007/164_2022_593

Abstract: The Chloride Channel (CLC) family includes proton-coupled chloride and fluoride transporters. Despite their similar protein architecture, the former exchange two chloride ions for each proton and are inhibited by fluoride, whereas the latter efficiently transport one fluoride in exchange for one proton. The combination of structural, mutagenesis, and functional experiments with molecular simulations has pinpointed several amino acid changes in the permeation pathway that capitalize on the different chemical properties of chloride and fluoride to fine-tune protein function. Here we summarize recent findings on fluoride inhibition and transport in the two prototypical members of the CLC family, the chloride/proton transporter from Escherichia coli (CLC-ec1) and the fluoride/proton transporter from Enterococcus casseliflavus (CLCF-eca).

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Contributing Institute(s):

1. Computational Biomedicine (IAS-5)
2. Computational Biomedicine (INM-9)

Research Program(s):

1. 5241 - Molecular Information Processing in Cellular Systems (POF4-524) (POF4-524)
2. DFG project 291198853 - FOR 2518: Funktionale Dynamik von Ionenkanälen und Transportern - DynIon - (291198853) (291198853)
3. DFG project 329460521 - Protonentransfer und Substraterkennung in SLC17-Transportern (329460521) (329460521)
4. GRK 2416 - GRK 2416: MultiSenses-MultiScales: Neue Ansätze zur Aufklärung neuronaler multisensorischer Integration (368482240) (368482240)

Appears in the scientific report 2024

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