Journal Article

FZJ-2024-03121

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Multiscale co-simulation design pattern for neuroscience applications

Kusch, L. (Corresponding author) ; Diaz, S.FZJ* ; Klijn, W.FZJ* ; Sontheimer, K.FZJ* ; Bernard, C. ; Morrison, A.FZJ* ; Jirsa, V. (Corresponding author)

2024
Frontiers Research Foundation Lausanne

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Please use a persistent id in citations: doi:10.3389/fninf.2024.1156683  doi:10.34734/FZJ-2024-03121

Abstract: Integration of information across heterogeneous sources creates added scientific value. Interoperability of data, tools and models is, however, difficult to accomplish across spatial and temporal scales. Here we introduce the toolbox Parallel Co-Simulation, which enables the interoperation of simulators operating at different scales. We provide a software science co-design pattern and illustrate its functioning along a neuroscience example, in which individual regions of interest are simulated on the cellular level allowing us to study detailed mechanisms, while the remaining network is efficiently simulated on the population level. A workflow is illustrated for the use case of The Virtual Brain and NEST, in which the CA1 region of the cellular-level hippocampus of the mouse is embedded into a full brain network involving micro and macro electrode recordings. This new tool allows integrating knowledge across scales in the same simulation framework and validating them against multiscale experiments, thereby largely widening the explanatory power of computational models.

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Contributing Institute(s):

1. Jülich Supercomputing Center (JSC)
2. Computational and Systems Neuroscience (IAS-6)
3. Computational and Systems Neuroscience (INM-6)

Research Program(s):

1. 5111 - Domain-Specific Simulation & Data Life Cycle Labs (SDLs) and Research Groups (POF4-511) (POF4-511)
2. 5232 - Computational Principles (POF4-523) (POF4-523)
3. 5234 - Emerging NC Architectures (POF4-523) (POF4-523)
4. SLNS - SimLab Neuroscience (Helmholtz-SLNS) (Helmholtz-SLNS)
5. HBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539) (945539)
6. HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907) (785907)
7. ICEI - Interactive Computing E-Infrastructure for the Human Brain Project (800858) (800858)

Appears in the scientific report 2024

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Database coverage:
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