Journal Article

FZJ-2019-02993

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Vault RNA emerges as a regulator of selective autophagy

Horos, R. (Corresponding author) ; Büscher, M. ; Sachse, C.FZJ* ; Hentze, M. W.

2019
Taylor & Francis Abingdon, Oxon

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Please use a persistent id in citations: doi:10.1080/15548627.2019.1609861

Abstract: The selective autophagic receptor SQSTM1/p62 ushers cargo to phagophores, the precursors of autophagosomes, and serves as a platform for autophagy initiation. We discovered that SQSTM1 is an RNA-binding protein that interacts with vault RNAs. Vault RNAs are small non-coding RNAs found in many eukaryotes and transcribed by POLR3 (RNA polymerase III). The levels of VTRNA1–1 (vault RNA 1-1) regulate SQSTM1-mediated autophagy and ubiquitin aggregate clearance. Vault RNA interferes with oligomerization of SQSTM1, which is in turn critical for its autophagic function. Our study uncovered a novel mode of regulation of a protein’s activity by RNA, termed riboregulation.

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Contributing Institute(s):

1. Strukturbiologie (ER-C-3)

Research Program(s):

1. 551 - Functional Macromolecules and Complexes (POF3-551) (POF3-551)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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