Journal Article

FZJ-2021-00991

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Photopenic Defects in Gliomas With Amino-Acid PET and Relative Prognostic Value

Zaragori, T. (Corresponding author) ; Castello, A. ; Guedj, E. ; Girard, A. ; Galldiks, N.FZJ* ; Albert, N. L. ; Lopci, E. ; Verger, A.

2021
Ovid [S.l.]

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Please use a persistent id in citations: http://hdl.handle.net/2128/28671  doi:10.1097/RLU.0000000000003240

Abstract: The aim is to explore the concept of photopenic defects in newly diagnosed glioma patients with the 2 widely used 11C-MET and 18F-FDOPA PET amino acid tracers. Thirty-two 11C-MET and 26 18F-FDOPA PET scans with amino acid PET-negative gliomas were selected in this European multicentric study. Of these gliomas, 16 11C-MET and 10 18F-FDOPA PET scans with photopenic defects were identified, exhibiting lower mean tumor-to-background ratio as compared with isometabolic gliomas (P < 0.001). Gliomas with photopenic defects had no different progression-free survival than isometabolic gliomas in the whole population (P = 0.40), but shorter progression-free survival in the subgroup of World Health Organization grade II IDH-mutant astrocytomas (35 vs 68 months; P = 0.047).

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 525 - Decoding Brain Organization and Dysfunction (POF4-525) (POF4-525)

Appears in the scientific report 2021

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Database coverage:
; ; ; Allianz-Lizenz ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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