Journal Article

FZJ-2021-03504

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Production of 6-L-[18F]Fluoro-m-tyrosine in an Automated Synthesis Module for 11C-Labeling

Orlovskaya, V. V. ; Craig, A. S. ; Fedorova, O. S. ; Kuznetsova, O. F. ; Neumaier, B. (Corresponding author)FZJ* ; Krasikova, R. N. ; Zlatopolskiy, B. D.

2021
MDPI Basel

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Please use a persistent id in citations: http://hdl.handle.net/2128/28648  doi:10.3390/molecules26185550

Abstract: 6-L-[18F]Fluoro-m-tyrosine (6-L-[18F]FMT) represents a valuable alternative to 6-L-[18F]FDOPA which is conventionally used for the diagnosis and staging of Parkinson’s disease. However, clinicalapplications of 6-L-[18F]FMT have been limited by the paucity of practical production methods for its automated production. Herein we describe the practical preparation of 6-L-[18F]FMT using alcoholenhancedCu-mediated radiofluorination of Bpin-substituted chiral Ni(II) complex in the presence of non-basic Bu4ONTf using a volatile iPrOH/MeCN mixture as reaction solvent. A simple and fast radiolabeling procedure afforded the tracer in 20.0 3.0% activity yield within 70 min. The developed method was directly implemented onto a modified TracerLab FX C Pro platform originally designed for 11C-labeling. This method enables an uncomplicated switch between 11C- and 18F-labeling. The simplicity of the developed procedure enables its easy adaptation to other commercially available remote-controlled synthesis units and paves the way for a widespread application of 6-L-[18F]FMT in the clinic.

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Contributing Institute(s):

1. Nuklearchemie (INM-5)

Research Program(s):

1. 5253 - Neuroimaging (POF4-525) (POF4-525)

Appears in the scientific report 2021

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