Journal Article

FZJ-2022-02275

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Heat management of a compact x‐ray source for microbeam radiotherapy and FLASH treatments

Winter, J. (Corresponding author) ; Dimroth, A. (Corresponding author)FZJ* ; Roetzer, S. ; Zhang, Y. ; Krämer, K.-L. ; Petrich, C. ; Matejcek, C. ; Aulenbacher, K. ; Zimmermann, M. ; Combs, S. E. ; Galek, M. ; Natour, G.FZJ* ; Butzek, M.FZJ* ; Wilkens, J. J. ; Bartzsch, S.

2022
AAPM College Park, Md.

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Please use a persistent id in citations: http://hdl.handle.net/2128/31485  doi:10.1002/mp.15611

Abstract: Background:Microbeam and x-ray FLASH radiation therapy are innovativeconcepts that promise reduced normal tissue toxicity in radiation oncology withoutcompromising tumor control. However, currently only large third-generationsynchrotrons deliver acceptable x-ray beam qualities and there is a need forcompact, hospital-based radiation sources to facilitate clinical translation ofthese novel treatment strategies.Purpose: We are currently setting up the first prototype of a line-focus x-raytube (LFxT), a promising technology that may deliver ultra-high dose rates(UHDRs) of more than 100 Gy/s from a table-top source. The operation of thesource in the heat capacity limit allows very high dose rates with micrometersizedfocal spot widths.Here,we investigate concepts of effective heat managementfor the LFxT, a prerequisite for the performance of the source.Methods: For different focal spot widths, we investigated the temperatureincrease numerically with Monte Carlo simulations and finite element analysis(FEA).We benchmarked the temperature and thermal stresses at the focal spotagainst a commercial x-ray tube with similar power characteristics.We assessedthermal loads at the vacuum chamber housing caused by scattering electrons inMonte Carlo simulations and FEA. Further,we discuss active cooling strategiesand present a design of the rotating target.

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Contributing Institute(s):

1. Zentralinstitut für Technologie (ZEA-1)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)
2. DFG project 416790481 - Tumortherapie mit Mikrostrahlen an kompakter Strahlenquelle (416790481) (416790481)

Appears in the scientific report 2022

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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