Journal Article

FZJ-2017-00190

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease.

Bischof, G. N. (Corresponding author)FZJ* ; Jessen, F. ; Fliessbach, K. ; Dronse, J. ; Hammes, J. ; Neumaier, B.FZJ* ; Onur, O.FZJ* ; Fink, G. R.FZJ* ; Kukolja, J. ; Drzezga, A. ; van Eimeren, T.FZJ*

2016
Wiley Chichester [u.a.]

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Please use a persistent id in citations: http://hdl.handle.net/2128/13399  doi:10.1002/acn3.339

Abstract: In a multimodal PET imaging approach, we determined the differential contribution of neurofibrillary tangles (measured with [18F]AV-1451) and beta-amyloid burden (measured with [11C]PiB) on degree of neurodegeneration (i.e., glucose metabolism measured with [18F]FDG-PET) in patients with Alzheimer's disease. Across brain regions, we observed an interactive effect of beta-amyloid burden and tau deposition on glucose metabolism which was most pronounced in the parietal lobe. Elevated beta-amyloid burden was associated with a stronger influence of tau accumulation on glucose metabolism. Our data provide the first in vivo insights into the differential contribution of Aβ and tau to neurodegeneration in Alzheimer's disease.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)
2. Nuklearchemie (INM-5)

Research Program(s):

1. 572 - (Dys-)function and Plasticity (POF3-572) (POF3-572)

Appears in the scientific report 2016

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Database coverage:
; ; ; ; DOAJ Seal ; Emerging Sources Citation Index ; NCBI Molecular Biology Database ; SCOPUS ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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