Journal Article

FZJ-2017-06369

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Optimized separation procedure for production of no-carrier-added radiomanganese for positron emission tomography

Buchholz, M. ; Spahn, I. (Corresponding author)FZJ* ; Coenen, H. H.FZJ*

2015
De Gruyter Berlin

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Please use a persistent id in citations: http://hdl.handle.net/2128/16357  doi:10.1515/ract-2015-2506

Abstract: The natCr(p, xn)-process is a very efficient route for production of 52gMn (T1/2 = 5.59 d). Based on measurements of distribution coefficients with different media and ion-exchange resins, an optimized chromatographic separation of radiomanganese from natCr with the resin Amberlite CG400 was developed. With this system natCr is eluted first with an acetic acid/methanol 1:1 mixture at room temperature and 52gMn thereafter with 3 M HCl at 50 ℃. Within a separation time of 4 h the method yielded 99.5% of the n.c.a. 52gMn in 2–3 mL of 3 M HCl. An ICP-MS analysis revealed a chromium impurity of 0.07 mg (0.014%) in the n.c.a. 52gMn solution, making this separation method suitable for the production of 52gMn for medical applications like positron emission tomography (PET).

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Contributing Institute(s):

1. Nuklearchemie (INM-5)

Research Program(s):

1. 573 - Neuroimaging (POF3-573) (POF3-573)

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Database coverage:
; ; Current Contents - Physical, Chemical and Earth Sciences ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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