Journal Article

FZJ-2022-05921

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png High‐Aspect‐Ratio Nanoelectrodes Enable Long‐Term Recordings of Neuronal Signals with Subthreshold Resolution

Shokoohimehr, P.FZJ* ; Cepkenovic, B.FZJ* ; Milos, F.FZJ* ; Bednár, J.FZJ* ; Hassani, H.FZJ* ; Maybeck, V.FZJ* ; Offenhäusser, A. (Corresponding author)FZJ*

2022
Wiley-VCH Weinheim

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Please use a persistent id in citations: http://hdl.handle.net/2128/33169  doi:10.1002/smll.202200053

Abstract: The further development of neurochips requires high-density and high-resolution recordings that also allow neuronal signals to be observed over a long period of time. Expanding fields of network neuroscience and neuromorphic engineering demand the multiparallel and direct estimations of synaptic weights, and the key objective is to construct a device that also records subthreshold events. Recently, 3D nanostructures with a high aspect ratio have become a particularly suitable interface between neurons and electronic devices, since the excellent mechanical coupling to the neuronal cell membrane allows very high signal-to-noise ratio recordings. In the light of an increasing demand for a stable, noninvasive and long-term recording at subthreshold resolution, a combination of vertical nanostraws with nanocavities is presented. These structures provide a spontaneous tight coupling with rat cortical neurons, resulting in high amplitude sensitivity and postsynaptic resolution capability, as directly confirmed by combined patch-clamp and microelectrode array measurements.

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Contributing Institute(s):

1. Bioelektronik (IBI-3)

Research Program(s):

1. 5241 - Molecular Information Processing in Cellular Systems (POF4-524) (POF4-524)

Appears in the scientific report 2022

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; DEAL Wiley ; Essential Science Indicators ; IF >= 15 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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